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Hum Exp Toxicol. 1995 Mar;14(3):294-8.

Amisulpride poisoning: a report on two cases.

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1
Institut de Médecine Légale, Faculté de Médecine de Strasbourg, France.

Abstract

The first two observations of human poisoning involving the recently developed neuroleptic amisulpride are described. In both cases drug determination was performed using reversed-phase HPLC coupled with diode array detection. Case 1 was a nonfatal overdosage in which the ingestion of 3.0 g amisulpride induced an attack of seizures, then light coma with agitation, hyperthermia, mydriasis, minimal extrapyramidal features, tachycardia and slight prolongation of the QT interval; the blood concentration of amisulpride was 9.63 micrograms ml-1. Case 2 was a fatality attributed to amisulpride in which the measured blood concentration was 41.70 micrograms ml-1. Our results are discussed in the light of data previously reported on the toxicity of substituted benzamides.

PMID:
7779461
DOI:
10.1177/096032719501400310
[Indexed for MEDLINE]
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