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Immunol Today. 1995 May;16(5):223-5.

Ligands for the T-cell receptor: hard times for avidity models.

Author information

1
Section of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.

Abstract

T-cell activation occurs when the T-cell receptor (TCR) binds to a self major histocompatibility complex (MHC) molecule carrying a specific peptide. Small changes in peptide structure can alter or inhibit this response. Although this phenomenon is normally attributed to a lowering of the avidity of the ligand for its receptor, recent data suggest that conformational changes in the receptor itself may be playing a critical role, as discussed here by Charles Janeway.

PMID:
7779252
DOI:
10.1016/0167-5699(95)80163-4
[Indexed for MEDLINE]

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