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Immunol Today. 1995 May;16(5):216-20.

Cytokine-binding proteins: stimulating antagonists.

Author information

1
Institute for Molecular Genetics, CNRS, Montpellier, France.

Abstract

Cytokine-binding proteins (CBPs) block the ability of cytokines to interact with their receptors. These agents can potentially provide a means of treating pathological conditions that have a significant cytokine involvement. However, a major drawback of such approaches relates to the fact that CBPs stabilize the cytokine in the form of a cytokine-CBP complex in vivo. Here, Bernard Klein and Hervé Brailly discuss the possibility that CBPs behave either as agonists or antagonists according to their pharmacokinetic characteristics in vivo, and suggest a mechanism by which stable complexes might be cleared from the system.

PMID:
7779250
DOI:
10.1016/0167-5699(95)80161-8
[Indexed for MEDLINE]

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