Abstract
The synthesis of (2'RS)-2'-methyl-, (3'RS)-, (3'S)-3'-methyl-, and 4'-methyl-delta 8-THC has been carried out, and the pharmacology of all four compounds has been investigated. All four compounds showed typical cannabinoid activity both in vitro and in vivo. The 2'-methyl compound is somewhat more active than delta 8-THC, while the 4'-methyl isomer is less active. The 3'-methyl-delta 8-THC has approximately the same activity as the parent cannabinoid.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Analgesics / chemistry
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Analgesics / pharmacology
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Animals
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Binding, Competitive
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Catalepsy / chemically induced
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Cyclohexanols / metabolism
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Dronabinol / analogs & derivatives*
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Dronabinol / chemistry
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Dronabinol / metabolism
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Dronabinol / pharmacology
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Hypothermia / chemically induced
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Mice
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Motor Activity / drug effects
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Structure-Activity Relationship
Substances
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Analgesics
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Cyclohexanols
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delta-8-tetrahydrocannabinol
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Dronabinol
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3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol