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Equine Vet J. 1995 Jan;27(1):13-8.

Absorption and dosage of theophylline in the horse after single and repeated administration of a microencapsulated preparation.

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Istituto di Farmacologia, Farmacocinetica e Tossicologia, Facoltà di Medicina Veterinaria, Università degli Studi di Bologna, Ozzano Emilia (BO), Italy.


The kinetics of 2 formulations of theophylline were studied in horses. In an initial cross-over study (Phase I) serum concentration-time curves were determined for granulated and microencapsulated theophylline after a single oral administration (5 mg/kg bwt). In Phase II microencapsulated theophylline was administered at 5 mg/kg bwt/12 h for 10 days at feeding time, as in normal clinical practice. Although no significant differences between the 2 preparations were found with respect to the main kinetic parameters, the microencapsulated form was more evenly and completely absorbed from the digestive tract; furthermore, after the repeated treatment, its trough-peak serum concentrations were always within the therapeutic window and no toxic effects were observed in treated animals.

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