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Curr Opin Struct Biol. 1995 Feb;5(1):103-13.

Protein-peptide interactions.

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Department of Molecular Biology MB13, Scripps Research Institute, La Jolla, CA 92037, USA.


Proteins can interact with short peptide sequences in a variety of ways that can be sequence dependent or independent. The bound peptides are frequently in an extended conformation but may also adopt beta-turns or alpha-helices as motifs for recognition. The peptides can be completely buried in cavities, bound in grooves or pockets, or form beta-strand type interactions at the protein surface. These various recognition motifs are illustrated by peptide interactions with antibodies, calmodulin, OppA periplasmic binding protein, PapD chaperone, MHC class I and class II molecules, and Src homology (SH) domains 2 and 3.

[Indexed for MEDLINE]

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