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Leuk Lymphoma. 1995 Mar;17(1-2):155-61.

Intestinal T-cell lymphoma with massive tissue and blood eosinophilia mediated by IL-5.

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  • 1Divisione di Medicina, University of Torino, Italy.


A case of enteropathy associated T-cell lymphoma (EATCL) in a 62-year-old female with a previous history of coeliac disease, complicated during the clinical course by massive blood and tissue eosinophilia is described. The patient's serum contained a factor capable of stimulating the in vitro growth of eosinophilic colonies (CFU-Eo), that was absent in the serum of normal donors. We suggest that such factor was Interleukin-5 (IL-5), as indicated by the presence in the monoclonal tumor T cells of IL-5 encoding mRNA, usually absent in the normal enterocytes of the jejunum.

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