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Curr Opin Neurobiol. 1995 Feb;5(1):55-61.

Targeting of mRNAs to subsynaptic microdomains in dendrites.

Author information

1
Department of Neuroscience, University of Virginia Health Sciences Center, Charlottesville 22908, USA.

Abstract

Recent studies have revealed that a heterogeneous population of mRNAs is present in neuronal dendrites (including mRNAs that encode proteins involved in intracellular signaling), that different types of neurons have different assortments of dendritic mRNAs, and that the levels of some dendritic mRNAs are up-regulated by activity. These findings reinforce and extend the hypothesis that the localization of mRNA in dendrites provides a means of synthesizing proteins locally that are important for synaptic function.

PMID:
7773006
DOI:
10.1016/0959-4388(95)80087-5
[Indexed for MEDLINE]

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