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Curr Opin Neurobiol. 1995 Feb;5(1):19-27.

Intrinsic and extrinsic factors regulating vertebrate neurogenesis.

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  • 1Department of Biological Sciences, University of Iowa, Iowa City 52242, USA.


Recent studies of the factors regulating neurogenesis in vertebrates reveal three emerging themes. First, the number of cellular stages involved in this process may be greater than has previously been appreciated. Second, homologues of genes that regulate neurogenesis in invertebrates appear to play analogous roles in development of vertebrate nervous systems. Third, extrinsic factors can act to regulate neuron number during neurogenesis by controlling survival and differentiation, and not simply proliferation, of neural progenitor cells.

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