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Brain Cogn. 1995 Mar;27(2):202-12.

Frontal lobe dysfunction in schizophrenia and obsessive-compulsive disorder: a neuropsychological study.

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1
Department of Biomedical and Technological Sciences, University of Milan Medical School, Italy.

Abstract

Converging evidence suggests there is a specific role of dorso-lateral-prefrontal cortex (DLPC) in schizophrenic disorders and of orbito-frontal cortex (OFC) in obsessive-compulsive disorder (OCD). Here, 25 schizophrenic and 25 OCD patients were evaluated with Wisconsin Card Sorting Test and Object Alternation Test; neuropsychological tools sensitive to DLPC and OFC damage, respectively; and compared with 25 subjects of a control group. Moreover, they all underwent Weigl's Sorting Test and the Word Fluency Test to assess global frontal functioning. The results indicated a DLPC deficit in schizophrenia and an OFC involvement in OCD. These data suggest that functional disorders of the central nervous system can be explored with neuropsychological instruments.

PMID:
7772333
DOI:
10.1006/brcg.1995.1017
[Indexed for MEDLINE]
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