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Arch Otolaryngol Head Neck Surg. 1995 Jun;121(6):678-80.

Treatment of experimental frostbite with pentoxifylline and aloe vera cream.

Author information

1
Division of Otolaryngology, Albany (NY) Medical College, USA.

Abstract

OBJECTIVE:

To compare the therapeutic effects of systemic pentoxifylline and topical aloe vera cream in the treatment of frostbite.

DESIGN:

The frostbitten ears of 10 New Zealand white rabbits were assigned to one of four treatment groups: untreated controls, those treated with aloe vera cream, those treated with pentoxifylline, and those treated with aloe vera cream and pentoxifylline.

MAIN OUTCOME MEASURES:

Tissue survival was calculated as the percent of total frostbite area that remained after 2 weeks.

RESULTS:

The control group had a 6% tissue survival. Tissue survival was notably improved with pentoxifylline (20%), better with aloe vera cream (24%), and the best with the combination therapy (30%).

CONCLUSION:

Pentoxifylline is as effective as aloe vera cream in improving tissue survival after frostbite injury.

[Indexed for MEDLINE]

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