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Trends Biochem Sci. 1995 Apr;20(4):151-6.

G beta gamma interactions with PH domains and Ras-MAPK signaling pathways.

Author information

1
Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA.

Abstract

G-protein-coupled receptor signaling and receptor tyrosine kinase (RTK) signaling are two mechanisms of transmembrane communication used by numerous extracellular agents and stimuli. The beta gamma-subunit complex of G proteins mediates many of the functions associated with G-protein-coupled receptor signaling and may even provide a means to link G proteins to RTK-initiated cascades. This connection may be mediated by the pleckstrin homology domain, a modular domain found in many signaling proteins that interact with G beta gamma.

PMID:
7770915
DOI:
10.1016/s0968-0004(00)88992-6
[Indexed for MEDLINE]

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