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Trends Biochem Sci. 1995 Apr;20(4):147-50.

Arf proteins: the membrane traffic police?

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Laboratory of Biological Chemistry, Developmental Therapeutics Program, DCT, NCI, Bethesda, MD 20892, USA.


Cofactor for cholera toxin; activator of phospholipase D; regulator of coat-protein assembly; inhibitor of membrane traffic; ability to cause expansion of the endoplasmic reticulum and vesiculation of the Golgi; sensitivity to membrane phospholipids--each of these activities has been attributed to Arf proteins. Can a single molecular mechanism link them all?

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