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Trends Biochem Sci. 1995 Apr;20(4):143-6.

The SWI-SNF complex: a chromatin remodeling machine?

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Program in Molecular Medicine, University of Massachusetts Medical Center, Worcester 01605, USA.


The SWI-SNF complex plays a key role in the regulation of eukaryotic gene expression. Genetic studies in the yeast Saccharomyces cerevisiae suggest that one role for the complex is to antagonize chromatin-mediated repression of transcription. Recent biochemical studies indicate that S. cerevisiae and putative human SWI-SNF complexes use the energy of ATP hydrolysis to disrupt nucleosome structure.

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