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Scand J Immunol. 1995 Jun;41(6):529-33.

A correlation between the expression of the bcr-abl chimeric gene and severity of the clinical state of CML patients with time.

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Molecular Genetics Unit, Rambam Medical Center, Haifa, Israel.


Using the reverse polymerase chain reaction, four Ph' positive CML patients were followed for 2 years; a correlation between the severity of the clinical state and the b3a2 expression was noted with time. Additionally, amplification of the c-myc proto-oncogene was observed, using Southern blot analysis, in one patient prior to his entry to the blast phase. No reorganization of the bcr-abl rearrangement site was found in the latter patient. The data suggest that a routine follow-up of CML patients using the Southern blot analysis and the reverse transcription-polymerase chain reaction might be of importance in evaluating the progression of the disease.

[Indexed for MEDLINE]

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