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J Antimicrob Chemother. 1995 Jan;35(1):167-71.

The role of lipopolysaccharide anionic binding sites in aminoglycoside uptake in Stenotrophomonas (Xanthomonas) maltophilia.

Author information

1
Pasteur Institute of Brabant, Antibiotic Research Unit, Brussels, Belgium.

Abstract

Aminoglycoside resistance was investigated in six clinical isolates of Stenotrophomonas (Xanthomonas) maltophilia by studying the uptake kinetics and by using a radiochemical method to detect aminoglycoside modifying enzymes. Furthermore, the lipopolysaccharides (LPS) were extracted and characterized by SDS-PAGE and chemical analysis. Dansyl-polymyxin displacement experiments confirmed the availability of anionic binding sites. Growing cells of the isolates bound dansyl-polymyxin but were not lysed.

PMID:
7768765
DOI:
10.1093/jac/35.1.167
[Indexed for MEDLINE]

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