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Eur J Pharmacol. 1995 Mar 14;275(3):R5-6.

Adenosine release in the ventral striatum of the rat is modulated by endogenous nitric oxide.

Author information

1
Department of Pharmacology and Toxicology, University of Innsbruck, Austria.

Abstract

The influence of nitric oxide (NO) on adenosine release was investigated by the push-pull technique in the ventral striatum of the urethane-anaesthetized rat. Superfusion with the NO donor diethylamine-NO enhanced, whereas superfusion with the NO synthase inhibitor L-NG-nitroarginine methyl ester decreased the output of adenosine. The effect of L-NG-nitroarginine methyl ester was abolished by L-arginine methyl ester. These findings indicate that, in the ventral striatum of the rat, NO modulates adenosine release.

PMID:
7768287
DOI:
10.1016/0014-2999(95)00097-5
[Indexed for MEDLINE]

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