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Development. 1995 Feb;121(2):589-99.

Nubbin encodes a POU-domain protein required for proximal-distal patterning in the Drosophila wing.

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Differentiation Programme, European Molecular Biology Laboratory, Heidelberg, Germany.


The nubbin gene is required for normal growth and patterning of the wing in Drosophila. We report here that nubbin encodes a member of the POU family of transcription factors. Regulatory mutants which selectively remove nubbin expression from wing imaginal discs lead to loss of wing structures. Although nubbin is expressed throughout the wing primordium, analysis of genetic mosaics suggests a localized requirement for nubbin activity in the wing hinge. These observations suggest the existence of a novel proximal-distal growth control center in the wing hinge, which is required in addition to the well characterized anterior-posterior and dorsal-ventral compartment boundary organizing centers.

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