Send to

Choose Destination
See comment in PubMed Commons below
Calcif Tissue Int. 1995 Apr;56(4):305-10.

Ovariectomy decreases the bone area fraction of the rat mandible.

Author information

Orthopedic Biomechanics Laboratory, Beth Israel Hospital, Boston, Massachusetts 02215, USA.


Although osteoporosis is a major public health concern, the effect of this condition on oral bone has not been determined. Using the ovariectomized rat, we tried to determine if estrogen depletion and aging affect the mandible of the rat. Sixty-one ovariectomized (ovx) and sham-operated (sham) 6-month-old Sprague Dawley rats were divided equally into six groups. The baseline, adult, and old rats were euthanized 14, 114, 200 days post-ovx, respectively. The bone mineral density of the mandible was measured using high resolution dual energy x-ray absorptiometry. The failure load and stiffness of the mandible were measured in three-point bending. The bone area fraction and area moment of inertia of digitized images of mandible sections were measured using image analyzing software. In adult rats, ovx led to a 15% and 28% increase in failure load and stiffness, respectively, but no change in bone area fraction or bone mineral density. In the old rats, ovx led to an 8% decrease in bone area fraction, but no change in failure load, stiffness, or bone mineral density of the mandible. In the ovx rats, aging led to a 20% and 7% decrease in stiffness and bone area fraction of the mandibles in the old rats compared with that in the adult rats. In the adult ovx rats, the increase in structural properties of the mandible may be a consequence of an increase in masticatory function as it has been reported that ovx rats eat approximately 10% more than sham controls.(ABSTRACT TRUNCATED AT 250 WORDS)

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center