Development of anti-Sm and anti-DNA antibodies followed by clinical manifestation of systemic lupus erythematosus in an elderly woman with long-standing Sjögren's syndrome

M Satoh; H Yamagata; F Watanabe; S Nakayama; T Ogasawara; T Tojo; M Akizuki

doi:10.1177/096120339500400113

Development of anti-Sm and anti-DNA antibodies followed by clinical manifestation of systemic lupus erythematosus in an elderly woman with long-standing Sjögren's syndrome

Lupus. 1995 Feb;4(1):63-5. doi: 10.1177/096120339500400113.

Authors

M Satoh¹, H Yamagata, F Watanabe, S Nakayama, T Ogasawara, T Tojo, M Akizuki

Affiliation

¹ Department of Internal Medicine, National Murayama Hospital, Tokyo, Japan.

PMID: 7767341
DOI: 10.1177/096120339500400113

Abstract

A 69-year-old Japanese women who had been followed up for 10 years as a primary Sjögren's syndrome, is reported. She suddenly developed serological and clinical characteristics of systemic lupus erythematosus (SLE): anti-Sm and anti-dsDNA antibodies followed by nephrotic syndrome and pancytopenia. This case suggests that the diagnosis of primary Sjögren's syndrome should be considered as tentative in certain cases and that the development of serological characteristics precede and are associated with the development of clinical symptoms of SLE.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Autoantibodies / blood*
Autoantigens / immunology*
DNA / immunology*
Diagnosis, Differential
Female
Humans
Lupus Erythematosus, Systemic / complications*
Lupus Erythematosus, Systemic / diagnosis
Lupus Erythematosus, Systemic / immunology
Nephrotic Syndrome / complications
Ribonucleoproteins, Small Nuclear / immunology
Sjogren's Syndrome / complications*
Sjogren's Syndrome / diagnosis
Sjogren's Syndrome / immunology
snRNP Core Proteins

Substances

Autoantibodies
Autoantigens
Ribonucleoproteins, Small Nuclear
snRNP Core Proteins
DNA