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Biosci Biotechnol Biochem. 1995 Jan;59(1):143-4.

Effects of alpha- and beta-arbutin on activity of tyrosinases from mushroom and mouse melanoma.

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1
Technical Research Laboratory, Kurabo Industries Ltd., Osaka, Japan.

Abstract

The effects of alpha- and beta-arbutin on the activity of tyrosinases from mushroom and mouse melanoma were examined. alpha-Arbutin was synthesized from hydroquinone and starch using glucoside synthetase (GSase). beta-Arbutin inhibited both tyrosinase activities from mushroom and mouse melanoma. alpha-Arbutin inhibited only the tyrosinase from mouse melanoma, 10 times as strongly as beta-arbutin. The IC50 of alpha-arbutin was 0.48 mM and its inhibitory mechanism was speculated to be mixed type inhibition, while that of beta-arbutin was noncompetitive.

PMID:
7765966
DOI:
10.1271/bbb.59.143
[Indexed for MEDLINE]
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