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Curr Opin Biotechnol. 1994 Dec;5(6):585-94.

Mismatch repair and cancer susceptibility.

Author information

1
Dana Farber Cancer Institute, Boston.

Abstract

Mismatch-repair systems have been identified in organisms ranging from Escherichia coli to humans. They can repair almost all DNA base pair mismatches as well as small insertion/deletion mismatches. Molecular and biochemical analyses have shown that the core components of eukaryotic mismatch-repair systems are highly homologous to their bacterial counterparts. In humans, defects in four mismatch-repair genes have been linked both to hereditary non-polyposis colorectal cancer and to spontaneous cancers that exhibit rearrangements in DNA containing simple repeat sequences.

PMID:
7765740
DOI:
10.1016/0958-1669(94)90079-5
[Indexed for MEDLINE]

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