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Curr Opin Biotechnol. 1994 Oct;5(5):482-6.

Applications of interaction traps/two-hybrid systems to biotechnology research.

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Harvard Medical School, Boston.


Two-hybrid methods provide a simple and sensitive means to detect the interaction between two proteins in living cells. Their use has resulted in the isolation of new proteins and has facilitated characterization of particular protein-protein interactions. These techniques have already resulted in the identification of important targets for pharmaceutical intervention, and it is likely that their extension in coming years will facilitate the development of new drugs.

[Indexed for MEDLINE]

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