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Trends Biotechnol. 1994 Jan;12(1):19-26.

Combinatorial chemistry--applications of light-directed chemical synthesis.

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1
Affymax Research Institute, Palo Alto, CA 94304.

Abstract

Combinatorial methods in biology and chemistry are proving to be powerful methods for generating molecular diversity. One approach, light-directed chemical synthesis, combines semiconductor-based photolithography technologies with solid-phase organic chemistry to synthesize large arrays of molecules with potential biological activity. This novel technology has the potential to provide libraries of both natural and synthetic molecules that might be screened rapidly for biological activity.

PMID:
7765338
DOI:
10.1016/0167-7799(94)90007-8
[Indexed for MEDLINE]
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