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Trends Biotechnol. 1994 Sep;12(9):346-52.

Eosinophilia-myalgia syndrome and tryptophan production: a cautionary tale.

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1
Allergic Diseases Research Laboratory, Mayo Clinic, Rochester, MN 55905.

Abstract

An epidemic of a new disease, termed eosinophilia-myalgia syndrome, occurred in the USA in 1989. This syndrome was linked to the consumption of L-tryptophan manufactured by a single company utilizing a fermentation process. All the findings indicate that the illness was probably triggered by an impurity formed when the manufacturing conditions were modified. This outbreak highlights the need for close monitoring of the chemical purity of biotechnology-derived products, and for rigorous testing of such products following any significant changes to the manufacturing process.

PMID:
7765187
DOI:
10.1016/0167-7799(94)90035-3
[Indexed for MEDLINE]
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