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Biosci Biotechnol Biochem. 1993 Jul;57(7):1231-3.

Stimulation of nerve growth factor production by pyrroloquinoline quinone and its derivatives in vitro and in vivo.

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1
Sagami Chemical Research Center, Kanagawa, Japan.

Abstract

Pyrroloquinoline quinone (PQQ), which is a cofactor of microbial quinoprotein enzymes, was found to be a potent enhancer of nerve growth factor (NGF) production in vitro. One of PQQ derivatives, oxazopyrroloquinoline trimethylester, had little activity in vitro, but increased the NGF content in rat brain in vivo.

PMID:
7764070
DOI:
10.1271/bbb.57.1231
[Indexed for MEDLINE]
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