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Biochem Biophys Res Commun. 1995 May 25;210(3):738-45.

Inhibition of glycogen synthase kinase-3 by insulin in cultured human skeletal muscle myoblasts.

Author information

1
Department of Biochemistry, University of Newcastle upon Tyne, UK.

Abstract

The acute effects of insulin on the activity of glycogen synthase kinase 3 (GSK-3) have been investigated both in the rat L6 muscle cell line and in cultured human myoblasts. The alpha and beta isoforms of GSK-3 are present in both cell types, with the beta isoform being predominant in the human cells. Insulin causes a rapid inactivation of both isoforms in both cell lines, with 50% inactivation being observed in the human myoblasts.

PMID:
7763247
DOI:
10.1006/bbrc.1995.1721
[Indexed for MEDLINE]

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