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Chemotherapy. 1995 Mar-Apr;41(2):121-4.

Clinical isolate of a Xanthomonas maltophilia strain producing L-1-deficient and L-2-inducible beta-lactamases.

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Istituto di Microbiologia Medica, Università di Catania, Italy.


Xanthomonas maltophilia produces two inducible beta-lactamases, L-1 and L-2, and resists the antimicrobial activity of beta-lactam antibiotics including carbapenems. L-1 has carbapenemase activity and L-2 is a cephalosporinase. It has been suggested that these beta-lactamases share regulatory components. We isolated a recent clinical X. maltophilia strain susceptible to carbapenems and resistant to almost all the other beta-lactam antibiotics tested. beta-Lactamase induction with cefotaxime showed that the clinical isolate had low-level expression of L-1 beta-lactamase but remained inducible for L-2 enzyme. The possible relationship of this enzyme to carbapenem sensitivity is considered.

[Indexed for MEDLINE]

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