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C R Acad Sci III. 1995 Jan;318(1):51-6.

[Fibroblast growth factor (FGF-2) and delayed involution of the posterior limbs of the slow-worm embryo (Anguis fragilis, L.)].

[Article in French]

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Laboratoire de Zoologie, Université Paul-Sabatier, Toulouse, France.


Administration at doses of 1,800 ng to 6,200 ng of basic fibroblast growth factor (bFGF), around the posterior limb buds of young slow-worm (Anguis fragilis, L.) embryos developing in cultured eggs has, after 4 to 6 days, in several embryos (10 among 15, treated at stage of allantoic bud, from 3 to 9 mm long), delayed the involution of these posterior limbs: their anlagen are larger than the control ones and histological examination shows an increase, between 20% and 30%, of cell density in the mesodermal component of the limb bud. These results bring into light the possibility to control, to some degree, the regressive evolution of the limbs.

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