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Hum Mol Genet. 1995 Feb;4(2):251-5.

The DXS423E gene in Xp11.21 escapes X chromosome inactivation.

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Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.


The DXS423E gene has been localized to Xp11.21 and is expressed in somatic cell hybrids retaining either the human active or inactive X chromosome, demonstrating that DXS423E escapes X chromosome inactivation. The XE169 (DXS1272E or SMCX) gene that escapes X chromosome inactivation is also located in Xp11.21-11.22 and maps within the same YAC as DXS423E. Thus the DXS423E and XE169 genes define a new region in the proximal short arm of the X chromosome that is not subject to X chromosome inactivation, supporting a regional basis for escape from inactivation.

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