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Biochem Biophys Res Commun. 1995 May 16;210(2):624-30.

Inhibition by haloperidol of adenosine 5'-triphosphate-evoked responses in rat pheochromocytoma cells.

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Division of Pharmacology, National Institute of Health Sciences, Tokyo, Japan.


The effects of haloperidol, a typical antipsychotic drug, on adenosine 5'-triphosphate (ATP)-induced increase in intracellular Ca2+ concentration ([Ca]i) and inward currents were investigated using rat pheochromocytoma PC12 cells. Haloperidol (10-100 microM) significantly attenuated the rise in [Ca]i evoked by 30 microM ATP. This inhibition was not mimicked by (-)-sulpiride, an antagonist to dopamine D2-receptor. Dopamine or other dopaminergic agents did not affect the [Ca]i rise evoked by ATP. Under whole-cell voltage-clamp, haloperidol inhibited the ATP-activated current in the cells. These results suggest that haloperidol inhibits the ATP-receptor/channel, leading to the attenuation of the ATP-evoked increase in [Ca]i. Mechanisms involving dopamine receptors may not contribute to the inhibition by haloperidol.

[Indexed for MEDLINE]

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