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Science. 1995 May 12;268(5212):866-9.

Identification and characterization of a prostaglandin transporter.

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1
Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Abstract

Carrier-mediated prostaglandin transport has been postulated to occur in many tissues. On the basis of sequence homology, the protein of unknown function encoded by the rat matrin F/G complementary DNA was predicted to be an organic anion transporter. Expression of the matrin F/G complementary DNA in HeLa cells or Xenopus oocytes conferred the property of specific transport of prostaglandins. The tissue distribution of matrin F/G messenger RNA and the sensitivity of matrin F/G-induced prostaglandin transport to inhibitors were similar to those of endogenous prostaglandin transport. The protein encoded by the matrin F/G complementary DNA is thus preferably called PGT because it is likely to function as a prostaglandin transporter.

PMID:
7754369
[Indexed for MEDLINE]
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