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Proc Natl Acad Sci U S A. 1995 May 9;92(10):4362-6.

Physical mapping, cloning, and identification of genes within a 500-kb region containing BRCA1.

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1
Somatic Cell Genetics Laboratory, Imperial Cancer Research Fund, London, United Kingdom.

Abstract

BRCA1 is a breast/ovarian cancer susceptibility gene on human chromosome 17q21. We describe a complete and detailed physical map of a 500-kb region of genomic DNA containing the BRCA1 gene and the partial cloning in phage P1 artificial chromosomes. Approximately 70 exons were isolated from this region, 11 of which were components of the BRCA1 gene. Analysis of the other exons revealed a rho-related G protein and the interferon-induced leucine-zipper protein IFP-35.

PMID:
7753812
PMCID:
PMC41944
[Indexed for MEDLINE]
Free PMC Article
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