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J Pediatr. 1995 May;126(5 Pt 1):762-4.

Permanent heterotopic ossification at the injection site after diphtheria-tetanus-pertussis immunizations in children who have fibrodysplasia ossificans progressiva.

Author information

1
Department of Orthopedic Surgery, University of Pennsylvania School of Medicine, Philadelphia 19104, USA.

Abstract

In patients who have fibrodysplasia ossificans progressiva, routine childhood diphtheria-tetanus-pertussis immunizations administered by intramuscular injection caused a significant risk of permanent heterotopic ossification at the site of injection (p < 10(-8)), whereas measles-mumps-rubella immunizations administered by subcutaneous injection posed no significant risk. Intramuscular injections should be avoided, if possible, once a diagnosis of fibrodysplasia ossificans progressiva has been established.

PMID:
7752003
DOI:
10.1016/s0022-3476(95)70408-6
[Indexed for MEDLINE]

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