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Can J Neurol Sci. 1995 Feb;22(1):50-1.

Pyridoxine dependent epilepsy with iatrogenic sensory neuronopathy.

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Department of Clinical Neurological Sciences, University of Western Ontario, University Hospital, London.


An 18-year-old man was treated from birth with chronic high dose pyridoxine (vitamin B6) up to 2000 mg per day for pyridoxine-dependent seizures. Within two years of onset of treatment, he developed a sensory neuropathy which did not progress over the following 16 years. Electrophysiological studies were consistent with a pure sensory neuronopathy expressed as centripetal degeneration of processes of the dorsal root ganglion cells.

[Indexed for MEDLINE]

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