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Curr Opin Genet Dev. 1995 Feb;5(1):84-90.

Biochemical properties and biological effects of p53.

Author information

1
Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel.

Abstract

Over the past year, insights have been made into the biochemistry and biological effects of p53. The high-resolution three-dimensional structure has been determined for the central core and carboxy-terminal domain of the protein, important p53 target genes (such as WAF1) have been identified, and insight has been gained into the relationship between p53-mediated growth arrest and apoptosis.

PMID:
7749331
DOI:
10.1016/s0959-437x(95)90058-6
[Indexed for MEDLINE]

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