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Biochimie. 1994;76(10-11):968-80.

The chromatin-associated protein H-NS.

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Imperial Cancer Research Fund Laboratories, University of Oxford, John Radcliffe Hospital, UK.


H-NS is a major component of chromatin in enteric bacteria. H-NS plays a structural role in organising the chromosome, and influences DNA rearrangements as well as the expression of many genes. The biochemical and functional characteristics of H-NS are distinct from those of 'typical' DNA-binding proteins and much remains to be learned about the mechanism(s) by which H-NS acts. In this article we review our current understanding of the role of H-NS, and describe possible models by which H-NS might influence DNA structure and gene expression.

[Indexed for MEDLINE]

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