Format

Send to

Choose Destination
Bioessays. 1995 Feb;17(2):97-9.

E-cadherin as a tumor (invasion) suppressor gene.

Author information

1
Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.

Abstract

Diffuse-type gastric carcinomas show diminished cell-cell adhesion. A recent paper reports that 50% of these carcinomas contain mutations in the E-cadherin gene, resulting in the destruction of the calcium-binding sites of E-cadherin, and providing strong in vivo evidence that alterations in E-cadherin play a major role in the development of this particular type of cancer and the short survival of the patients.

PMID:
7748170
DOI:
10.1002/bies.950170203
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center