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Brain Res. 1995 Jan 30;670(2):347-50.

Effect of Leu-enkephalin on the memory reactivation produced by blockade of the benzodiazepine/GABA-chloride ionophore receptor complex.

Author information

1
Department of Central Mechanisms of Regulation, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk.

Abstract

This investigation sought to characterize the interaction between GABA/benzodiazepine and opioid systems in memory retrieval deficit induced by detaining an animal in the training apparatus after acquisition. Mice pretreated with saline or Leu-enkephalin (0.2 mg/kg) were trained in one-trial passive avoidance test with following detention. Pre-testing administration of bicuculline (1 mg/kg), picrotoxin (1 mg/kg), or flumazenil (10 mg/kg) produced the memory-enhancing effect in the saline-pretreated mice. Pretraining treatment with Leu-enkephalin blocked the reactivation of memory produced by bicuculline and picrotoxin, but not flumazenil. The present investigation suggest that both benzodiazepine/GABA and opioid systems are important modulators of memory retrieval and that a specific interaction between these systems is responsible for the observed recovery of impaired memory trace.

PMID:
7743204
DOI:
10.1016/0006-8993(94)01361-k
[Indexed for MEDLINE]

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