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Bull Cancer. 1994 Jul;81(7):587-92.

[Study of mdm2 gene amplification in primary breast tumors].

[Article in French]

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Laboratoire de radioanalyse, centre Antoine-Lacassagne, Nice, France.


mdm2 (mouse double minute) protein seems lead to p53 inactivation and therefore might potentially play a role in carcinogenesis. We have studied mdm2 gene amplification from 239 primary breast cancer tissues. mdm2 gene was amplified in 10% of cases (25/239). mdm2 amplification was associated with c-erbB2 amplification (P < 10(-3)). No other correlation was found. However there was inverse correlation between c-erbB2 gene amplification and hormonal receptors (P < 10(-4)), only from patients without mdm2 gene amplification.

[Indexed for MEDLINE]

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