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FEMS Microbiol Lett. 1995 Mar 15;127(1-2):29-34.

Defective sterol delta 5(6) desaturase as a cause of azole resistance in Ustilago maydis.

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Krebs Institute for Biomolecular Research, Department of Molecular Biology and Biotechnology, University of Sheffield, UK.


Resistance to azole antifungals in Ustilago maydis was associated with a leaky defect in sterol delta 5(6)desaturase. This defect resulted in reduced accumulation of 14 alpha-methylergosta-24(28)-diene-3 beta,6 alpha-diol and an increase in the proportion of 14 alpha-methylfecosterol in treated cells when compared to the parent strain. The results demonstrate the importance of this mechanism in pathogenic fungi.

[Indexed for MEDLINE]

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