Format

Send to

Choose Destination
Eur J Pharmacol. 1995 Feb 6;273(3):303-6.

Vinpocetine is as potent as phenytoin to block voltage-gated Na+ channels in rat cortical neurons.

Author information

1
CNS Pharmacology Laboratory, Chinoin Co. Ltd., Budapest, Hungary.

Abstract

The effects of vinpocetine and phenytoin on voltage-gated Na+ channels were examined on cultured cerebrocortical neurones of the rat using a conventional whole-cell patch-clamp method. Vinpocetine and phenytoin decreased Na+ currents in a concentration-dependent manner, with IC50 values of 44.2 +/- 14.6 and 50.5 +/- 17.4 microM, respectively. Both compounds shifted the voltage dependence of the steady-state inactivation of the channel in the hyperpolarising direction. This pronounced Na+ channel blocking activity may contribute to the neuroprotective and anticonvulsant effects of vinpocetine.

PMID:
7737339
DOI:
10.1016/0014-2999(94)00755-v
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center