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Cancer Genet Cytogenet. 1995 Apr;80(2):115-7.

Sister chromatid exchange (SCE) studies in breast cancer patients: a follow-up study.

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1
Department of Human Genetics, Guru Nanak Dev University, Amritsar, India.

Abstract

Sister chromatid exchanges (SCEs) were studied in 20 patients with breast cancer (stage II) before surgery, one month after surgery, and after three years as a follow-up study. Data from 50 age-matched, normal healthy females, preferably from the affected families, served as controls. In each patient, 50 well-spread metaphases were scored for SCEs. The mean values of SCEs per metaphase were 5.80, 4.69, and 5.98 in breast cancer patients before surgery, one month after surgery, and after a gap of three years as a follow-up, respectively. The one-way analysis of variance was applied and it was found that there was a highly significant difference in the frequency of sister chromatid exchanges in these patients before surgery, one month after surgical removal of cancerous tissue, and after three years as a follow-up study. The elevated level of SCEs three years after surgical removal of cancerous tissue predict the chances of development of another type of cancer.

PMID:
7736426
DOI:
10.1016/0165-4608(94)00175-b
[Indexed for MEDLINE]

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