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Int J Obes Relat Metab Disord. 1995 Feb;19(2):103-7.

CNS involvement in the glucose induced increase of islet blood flow in obese Zucker rats.

Author information

1
Laboratoire de Physiopathologie de la Nutrition, CNRS URA 307, Université Paris VII, France.

Abstract

OBJECTIVES:

The aim of this work was to study the role of the central nervous system in the glucose-induced increase in islet blood flow in obese Zucker rats.

DESIGN:

A small amount of glucose (9 mg/kg) was injected towards the brain via the left carotid artery in lean obese rats either intact or vagotomized and after a pretreatment with clonidine.

RESULTS:

Glucose injection induced a significant increase in plasma insulin level and islet blood flow without a significant change in plasma glucose concentration in both lean and obese rats. Prior vagotomy or clonidine injection resulted in a decrease in glucose-induced islet blood flow. Both the effect of glucose and its reversal were more pronounced in obese rats.

CONCLUSION:

In obese rats, an alteration of the CNS could result in an increase in the parasympathetic tone and a decrease in the sympathetic one. These alterations would in turn contribute to the modifications in islet blood flow.

PMID:
7735335
[Indexed for MEDLINE]

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