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Immunol Today. 1995 Apr;16(4):176-81.

T-cell repertoire diversity and clonal expansions in normal and clinical samples.

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Unité de Biologie Moléculaire du Gène, INSERM, Institut Pasteur, Paris, France.


Improved polymerase chain reaction (PCR)-based methods now permit a more in-depth analysis of the repertoire of T cells recovered in biological samples from mice and humans. At a certain level of resolution, the diversity of the T-cell repertoire can be readily estimated and clonal expansions become easily detectable. As discussed here by Christophe Pannetier, Jos Even and Philippe Kourilsky, these improvements allow a better appreciation of the degree of reproducibility of immune responses, both in mice and humans, and should have a significant impact on clinical investigations.

[Indexed for MEDLINE]

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