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Trends Genet. 1995 Mar;11(3):101-5.

Regulators of cell death.

Author information

1
Department of Medicine and Pathology, Howard Hughes Medical Institute, Washington University School of Medicine, Saint Louis, MO 63110, USA.

Abstract

A novel oncogene-derived protein, Bcl-2, functions as a repressor of cell death in a genetic pathway of cellular suicide that appears to be common to all multicellular animals. A related protein that promotes cell death, Bax, wrestles with Bcl-2 through conserved motifs, BH1 and BH2, establishing a set point for these deaths. In Bcl-2-deficient mice, the ratio of these molecules is reset, resulting in massive cell death in several cell types.

PMID:
7732571
DOI:
10.1016/S0168-9525(00)89010-1
[Indexed for MEDLINE]

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