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J Antimicrob Chemother. 1994 Dec;34(6):921-30.

Decreased bactericidal activity during the period of the postantibiotic effect.

Author information

1
Department of Medicine, Landspitalinn (University Hospital, Reykjavik, Iceland.

Abstract

Standard and clinical strains of Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae were subjected to continuous exposure to beta-lactams and aminoglycosides during the postantibiotic effect phase induced by rifampicin or erythromycin (for S. aureus). A significant inhibition of bactericidal activity by these agents during the PAE period was observed. The degree of inhibition was dependent both on the class of antimicrobial agent (beta-lactams > aminoglycosides) and the microorganism (Gram-negative bacilli > S. aureus).

PMID:
7730235
DOI:
10.1093/jac/34.6.921
[Indexed for MEDLINE]

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