Send to

Choose Destination
Exp Parasitol. 1995 May;80(3):373-81.

Interactions of atovaquone with other antimalarial drugs against Plasmodium falciparum in vitro.

Author information

Pharmaceutical Systems Incorporated, Gaithersburg, Maryland 20879, USA.


A series of Plasmodium falciparum in vitro drug sensitivity studies were conducted in order to evaluate atovaquone in combination with other antimalarial drugs and thus to identify a potential partner for a fixed combination. The derived isobolograms indicated that drug interactions ranged from antagonism through addition to synergy. Of particular note were the quinolines and artemisinin analogues, which were all antagonistic, and the biguanides and tetracycline, which showed synergy. Proguanil emerged as the most promising of the current antimalarials as a partner for atovaquone in a fixed combination, with tetracycline as back-up.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center