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Ann Surg. 1995 Apr;221(4):392-7.

Hepatic metastases from soft-tissue sarcoma.

Author information

1
Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

Abstract

OBJECTIVE:

Hepatic metastases from soft-tissue sarcoma are evaluated to define treatment and its limitations.

METHODS:

From 981 adult patients with diagnoses of soft-tissue sarcoma, 65 patients with hepatic metastases were studied.

RESULTS:

An intra-abdominal primary site was present in 61 of 65 patients, with 85% high-grade leiomyosarcoma. Hepatic resection was performed in 14 patients (22%). All patients have had recurrences after hepatic resection-11 of 14 in the liver--with a median survival of 30 months. Chemotherapy resulted in partial response in three patients and no complete responses. Survival is not influenced by grade, type, primary site, disease-free interval, chemotherapy, or hepatic resection.

CONCLUSIONS:

The uncommon response to conventional chemotherapy does not support its use in the treatment of hepatic metastases from soft-tissue sarcoma. Extent of disease limits the application and success of hepatic resection for soft-tissue sarcoma, and anything less than complete resection is not indicated.

PMID:
7726675
PMCID:
PMC1234589
[Indexed for MEDLINE]
Free PMC Article

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