Format

Send to

Choose Destination
Am J Psychiatry. 1995 May;152(5):792-4.

Double-blind, controlled trial of inositol treatment of depression.

Author information

1
Yehuda Abarbanel Mental Health Center, Bat Yam, Israel.

Abstract

OBJECTIVE:

CSF levels of inositol have been reported to be lower than normal in depressed subjects. The authors administered inositol to depressed patients in a double-blind, controlled trial.

METHOD:

Under double-blind conditions, 12 g/day of inositol (N = 13) or placebo (N = 15) was administered to depressed patients for 4 weeks.

RESULTS:

The overall improvement in scores on the Hamilton Depression Rating Scale was significantly greater for inositol than for placebo at week 4. No changes were noted in hematology or in kidney or liver function.

CONCLUSIONS:

This may be the first use of the precursor strategy for a second messenger rather than a neurotransmitter in treating depression. Although inositol had a significant antidepressant effect in this study, replication is crucial.

PMID:
7726322
DOI:
10.1176/ajp.152.5.792
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center